I don't use rim locks. I do run the nut on the tube filler neck up toward the valve end and hand tighten it to the cap. That way, if there is any tire creep, the neck will become slanted and signal a problem. As others have said, with new rubber and higher pressures, it just doesn't seem to happen. I think rim locks still have a place on dirt bikes, but that's another story.
ClassicBiker is right that if the rim has a hole, it should somehow be covered. And that cover had better not have anything sharp on the inside. It had also better be very secure, so as not to pinch the tube.
Gary